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The antibiotic resistome: gene flow in environments, animals and human beings
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 161-168 doi: 10.1007/s11684-017-0531-x
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics. Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide range of antibiotics. The ARGs in natural environments are highly integrated and tightly regulated in specific bacterial metabolic networks. However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicine and agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulation of ARGs in bacteria. In this review, we summarized, with an emphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments, human and animals, i.e., in the one health settings. We propose that the resistance gene flow in nature is “from the natural environments” and “to the natural environments”; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene “circulation.”
Assessment of antibiotic resistance genes in dialysis water treatment processes
Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1136-1
• Quantitative global ARGs profile in dialysis water was investigated. • Totally 35 ARGs were found in the dialysis treatment train. • 29 ARGs (highest) were found in carbon filtration effluent. • erm and mtrD-02 occurred in the final effluent. • The effluent was associated with health risks even after RO treatment.
关键词: Dialysis water Treatment process Antibiotic resistance gene High-throughput quantitative PCR Horizontal gene transfer
Mengli Wang, Ruying Li, Qing Zhao
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1127-2
Sludge digestion is critical to control the spread of ARGs from wastewater to soil. Fate of ARGs in three pretreatment-AD processes was investigated. UP was more efficient for ARGs removal than AP and THP in pretreatment-AD process. The total ARGs concentration showed significant correlation with 16S rRNA gene. The bacteria carrying ARGs could be mainly affiliated with Proteobacteria.
关键词: Tetracycline resistance genes Sulfonamide resistance genes 16S rRNA gene Sludge pretreatment Anaerobic sludge digestion
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1682-4
● Abundance of MAGs carrying ARG-VF pairs unchanged in rivers after WWTP upgrade.
关键词: Wastewater treatment plant upgrade Antibiotic resistance genes (ARGs) Virulence factors (VFs) Gene co-occurrence Genome-centric analysis
Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu
《环境科学与工程前沿(英文)》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1189-1
关键词: Drinking water treatment Antibiotic resistance gene Biofiltration Chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
关键词: Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1469-4
• Distribution of ARGs in decentralized sewage facilities were investigated.
关键词: Decentralized sewage treatment facilities Antibiotic resistance genes Virus Metagenomics Network analysis
Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions
Xin Yu, Virender K. Sharma, Hui Li
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1137-0
Analysis of antibiotic resistance of
Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1123-6
The concentrations of four types of antibiotics in the Yitong River were detected. The concentration of total coliforms in summer was higher than that in spring. There was a seasonal difference in antibiotic resistance of E. coli. The E. coli in the Yitong River was found to have multiple antibiotic resistance.
关键词: Yitong River Coliform bacteria Antibiotic resistance Escherichia coli
Effect of ultraviolet irradiation and chlorination on ampicillin-resistant
Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU
《环境科学与工程前沿(英文)》 2016年 第10卷 第3期 页码 522-530 doi: 10.1007/s11783-015-0779-9
关键词: antibiotic resistance Escherichia coli ampicillin resistance gene ultraviolet irradiation chlorination
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
《农业科学与工程前沿(英文)》 2020年 第7卷 第3期 页码 329-332 doi: 10.15302/J-FASE-2020333
The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.
关键词: agroecosystem antibiotic resistance public health soil-plant system
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1120-9
Reviewed the change of ARGs and ARB in full-scale urban drinking water systems. Conventional processes are more promising than BAC process in ARGs removal. Mechanisms of ARGs enrichment and spread in BAC filter and DWDSs are discussed. Raise the need of future research on ARGs and ARB change in building plumbing systems.
关键词: Antibiotic resistant bacteria Antibiotic resistance genes Water source Drinking water treatment plant Drinking water distribution system Urban drinking water system
ARGs-OAP v3.0——抗生素耐药基因数据库的筛选和分析流程优化 Article
Xiaole Yin, Xiawan Zheng, Liguan Li, An-Ni Zhang, Xiao-Tao Jiang, Tong Zhang
《工程(英文)》 2023年 第27卷 第8期 页码 234-241 doi: 10.1016/j.eng.2022.10.011
Antibiotic resistance, which is encoded by antibiotic-resistance genes (ARGs), has proliferated to become a growing threat to public health around the world. With technical advances, especially in the popularization of metagenomic sequencing, scientists have gained the ability to decipher the profiles of ARGs in diverse samples with high accuracy at an accelerated speed. To analyze thousands of ARGs in a highthroughput way, standardized and integrated pipelines are needed. The new version (v3.0) of the widely used ARGs online analysis pipeline (ARGs-OAP) has made significant improvements to both the reference database—the structured ARGs (SARG) database—and the integrated analysis pipeline. SARG has been enhanced with sequence curation to improve annotation reliability, incorporate emerging resistance genotypes, and determine rigorous mechanism classification. The database has been further organized and visualized online in the format of a tree-like structure with a dictionary. It has also been divided into sub-databases for different application scenarios. In addition, the ARGs-OAP has been improved with adjusted quantification methods, simplified tool implementation, and multiple functions with userdefined reference databases. Moreover, the online platform now provides a diverse biostatistical analysis workflow with visualization packages for the efficient interpretation of ARG profiles. The ARGs-OAP v3.0 with an improved database and analysis pipeline will benefit academia, governmental management, and consultation regarding risk assessment of the environmental prevalence of ARGs.
关键词: SARG database ARGs-OAP Antibiotic-resistance genes Environmental metagenome Quantification
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
《医学前沿(英文)》 2021年 第15卷 第5期 页码 693-703 doi: 10.1007/s11684-020-0777-6
关键词: S. typhi antibiotic resistance mechanism resistome identification methods
Qingkun Ji, Caihong Zhang, Dan Li
《环境科学与工程前沿(英文)》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1287-0
关键词: Nanofullerene Sub-minimum inhibitory concentrations Antibiotic resistance genes Conjugation Molecular biological techniques
标题 作者 时间 类型 操作
Assessment of antibiotic resistance genes in dialysis water treatment processes
Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng
期刊论文
Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline
Mengli Wang, Ruying Li, Qing Zhao
期刊论文
Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence
期刊论文
Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review
Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu
期刊论文
Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
期刊论文
Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized
期刊论文
Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions
Xin Yu, Virender K. Sharma, Hui Li
期刊论文
Analysis of antibiotic resistance of
Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan
期刊论文
Effect of ultraviolet irradiation and chlorination on ampicillin-resistant
Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU
期刊论文
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
期刊论文
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
期刊论文
ARGs-OAP v3.0——抗生素耐药基因数据库的筛选和分析流程优化
Xiaole Yin, Xiawan Zheng, Liguan Li, An-Ni Zhang, Xiao-Tao Jiang, Tong Zhang
期刊论文